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- W2349127937 abstract "Objective To explore the relationship of serum proinsulin (PI) and true insulin (TI) concentrations to blood pressure (BP) in hypertensives. Methods Serum levels of PI and TI in 66 nondiabetic subjects with essential hypertension (EH, systolic/diastolic BP ≥140/90 mm Hg) and 73 normotensives (NT) during 2 h 75 g oral glucose tolerance test were measured by specific monoclonal antibody based amplified ELISAs, which had no cross reaction with each other. Systolic/diastolic BP, blood glucose (BG) and serum lipids were also analyzed. Results After adjusting for age, body mass index (BMI) and waist to hip ratio (WHR), the 2 h PI and PI/TI ratio were significantly higher in EH group than in NT group [(41.7±2.5) pmol/L vs. (26.9±2.9) pmol/L and 0.305±0.026 vs. 0.205±0.035, respectively, P 0.05], but TI levels between the two groups had no statistic difference. Correlation analysis showed that systolic BP (SBP) significantly associated with fasting and 2 h PI as well as 2 h PI/TI ratio, while diastolic BP merely correlated with 2 h PI/TI ratio. The correlation of TI with SBP was only found in non obese subjects. Multivariate regression analysis demonstrated that 2 h PI remained significantly associated with hypertension and SBP after adjustment for potentially confounding factors.Conclusion Post glucose hyperproinsulinemia exists in EH subjects of the study group and serum PI, but not TI, is positively associated with hypertension." @default.
- W2349127937 created "2016-06-24" @default.
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- W2349127937 date "2001-01-01" @default.
- W2349127937 modified "2023-09-27" @default.
- W2349127937 title "Association of serum proinsulin and true insulin levels with hypertension" @default.
- W2349127937 hasPublicationYear "2001" @default.
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