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- W2349163177 abstract "Objective To explore the effect of selective head mild hypothermia on interleukin-1β(IL-1β),interleukin-2(IL-2)and tumor necrosis factor alpha(TNF-α)in serum of neonatal hypoxic-ischemic encephalopathy(HIE)and those clinical significance.Methods Fifty neonates with moderate or severe HIE were randomly assigned into treatment group(n=25)and control group(n=25).Selective head mild hypothermia was used within 6 hours after birth to keep nasopharyngeal temperature at(34.0±0.5)℃ and rectal temperature at(35.5±0.5)℃ for 72 hours in treatment group,and control group got routine treatment.The dynamic changes of serum IL-1β,IL-2 and TNF-α within 6,24 and 72 hours respectively after birth were monitored using enzyme-linked immunosorbent assay(ELISA).Results Levels of serum IL-1β,IL-2 and TNF-α decreased more significantly at 24 and 72 hours in moderate HIE treatment group than those in control group(Pa0.05).Levels of serum IL-1β and IBF-α at 72 hours between severe HIE treatment group and control group had a significant difference(P0.05),and the level of serum IL-1 at 24 hours also had significant difference between severe HIE treatment group and control group(P0.05).Conclusion Selective head mild hypothermia has the protective effects on brains by relieving immunity." @default.
- W2349163177 created "2016-06-24" @default.
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- W2349163177 date "2008-01-01" @default.
- W2349163177 modified "2023-09-24" @default.
- W2349163177 title "Effect of Selective Head Mild Hypothermia on Serum Cytokines Levels of Neonatal Hypoxic-Ischemic Ence-phalopathy" @default.
- W2349163177 hasPublicationYear "2008" @default.
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