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- W2349190238 abstract "Objective To study the relationship among the activation of nuclear factor kB(NF kB), expression of intercecullar adhesion molecule 1(ICAM 1) and adhesion rate of polymorphonuclear neutriphils EC 340(PMN EC 340) in myocardial ischemic reperfusion(IR). Methods Twenty four Newzeland rabbits were divided into three groups,8 rabbits each group.Group 1: rabbits were subjected to total occlusion 45min of left anterior desending artery(LAD) followed reperfusion, group 2: pyrrolidine dithiocarbamate(PDTC) 15mg/kg, pretreated rabbits 10 min before ischemia, contral group: rabbits were not subjected to occlusion of artery. The blood and ischemic myocardial samples were studied before ischemia ,30 min,60 min,90 min,120 min,240 min, and 360 min after ischemia reperfusion.The expression levels of ICAM 1 were evaluated by flow cytometry ,activation of NF kB by electrophoretic mobility shift assay(EMSA), the adhesion rate of PMN EC 340 were measured. Results In group 1, the expression levels of ICAM 1 were increased at 120 min and had positive correlation to the adhesion rate of PMN EC 340;activation of NF kB were increased significantly after IR 30 min and reached a peak at 120 min,then decreased. In group 2, the expression levels of ICAM 1, activation of NF kB and adhesion rate of PMN EC 340 were increased,but lower than that in group 1 ( P =0 041,0 029,0 034). Conclusion The inducible activation of NF kB starts up ICAM 1 expression of PMN and it is an important factor in myocardial IR injury." @default.
- W2349190238 created "2016-06-24" @default.
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- W2349190238 date "2002-01-01" @default.
- W2349190238 modified "2023-09-24" @default.
- W2349190238 title "Activation Change of Nuclear Factor-kB and Influence on Adhesion of Polymorphonuclear Neutriphils in Myocardial Ischemic-reperfusion Injury" @default.
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