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- W2349203551 abstract "[Objective] To establish CIN models in mice with 7, 12-dimethylbenz[a]anthracene(DMBA). [Method] DMBA was resolved in benzene, where in the central portion of a cotton yarn was immersed in it. The DMBA-coated yarn was inserted into the cervixes of mice. The animals sacrificed after 5 months were observed. Studies were proceed through microscope. [Result] After carcinogen DMBA was applied the cervical epithelia of the mice underwent a series of pathological changes from atypical hyperplasia culminating in carcinoma. It is similar with CIN of human in biological features. [Conclusion] DMBA can induce CIN in mice and it can serve as a model for the study of CIN." @default.
- W2349203551 created "2016-06-24" @default.
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- W2349203551 date "2008-01-01" @default.
- W2349203551 modified "2023-09-25" @default.
- W2349203551 title "Establishment and preliminary observation of 7, 12-dimethylbenz[a]anthracene-induced CIN in mice" @default.
- W2349203551 hasPublicationYear "2008" @default.
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