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- W2349205519 abstract "Objective Many studies showed that Ca~(2+) channel blocker could prevent and treat right ventricular hypertrophy(RVH) induced by chronic hypoxia.To further identify the mechanism,we investigated the effect of Ca~(2+) channel blocker on the levels of myocardial calcineurin AβmRNA(CnAβ)in RV and plasma nitric oxide(NO),NO synthase and endothelin-1(ET-1) in rats with chronic hypoxia.Methods 30 rats were divided into three groups by randomized block design: treatment group with Amlodipine Besylate ablets [(30 mg·kg~(-1)·d~(-1)),administered via gavage],chronic hypoxia group,and control group.The rats in treatment group and chronic hypoxia group were exposed to normobaric chronic hypoxia [(10.0±0.5)% O_2 ] for 21 days.On the 21st day of experiment,all rats were sacrificed and the hearts were collected for measuring the weight.Blood samples were also drawn from the ventricles for measuring plasma NO,iNOS and ET-1 levels.CnAβmRNA levels in RV were measured by RT-PCR.Results ⑴The RV/(LV+S)、RV/BW ratios were significantly higher in chronic hypoxia group than those of control group and treatment group(P0.01);⑵RV CnAβmRNA levels in chronic hypoxia group were higher than those of treatment group and normal control group(P0.01);⑶ The levels of plasma NO,iNOS were significantly lower in chronic hypoxia group than those of control group and treatment group,however,the levels of ET-1 were significantly higher in chronic hypoxia group than those of control group and treatment group(P0.01).Conclusion Ca~(2+) channel blocker(Amlodipine Besylate) effectively inhibited RVH induced by chronic hypoxia,which might be related to its function of modulating the levels of NO,iNOS,and ET-1 in plasma,relieving the pulmonary hypertension and decreasing the levels of CnAβmRNA in RV." @default.
- W2349205519 created "2016-06-24" @default.
- W2349205519 creator A5080283047 @default.
- W2349205519 date "2006-01-01" @default.
- W2349205519 modified "2023-09-23" @default.
- W2349205519 title "Effect of Ca~(2+) channel blocker on the levels of myocardial calcineurin AβmRNA in right ventricle and plasma NO,nitric oxide synthase and endothelin-1 in rats with chronic hypoxia" @default.
- W2349205519 hasPublicationYear "2006" @default.
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