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• W2349205760 abstract "Objective To investigate the validity of using fasting blood glucose(FBG)and glycosylated serum albumin(GA) for the screening of diabetes. Methods 869 subjects(633 men, 236 women) over the age of 20 in our hospital physical examination center line underwent health check-up for screening diabetes between April 2013 and April 2014. Their average age was(42.95 ± 12.3)years. FBG and GA were examined at the same time on an empty stomach for 10 h. When FBG 7.0 mmol/L and ≥ 6.1 mmol/L or GA ≥ 18.5 %, OGTT was necessary to verify the diagnosis of diabetes. Results According to 1999 WHO criteria, 834 patients were normal, while 35 patients had diabetes. Using a receiver operating characteristic curve(ROC), the optim al cut-point of FBG related to diabetes diagnosed by OGTT was 6.2mmol/L that was associated with a sensitivity and specifi city of 97.1 % and 96.0 % respectively. Area under the curve(AUC) was 0.988(95 % CI 0.980 ~ 0.996), a positive likelihood ratio(LR)was 24.55, and a negative LR was 0.03. The optimal cut-point of GA related to diabetes diagnosed by OGTT was 14.55 %, which was associated with a sensitivity and specifi city of 82.8 % and 90.2 % respectively. Area under the curve(AUC) was 0.923(95 % CI 0.870 ~ 0.975), a positive LR was 8.43, and a negative LR was 0.19. When screening for DM, the result of the AUC for the FBG=6.2(0.988) GA=0.988(0.923), indicating higher FBG screening accuracy. Joint test can improve the effi ciency of screening, series of experiments that FBG ≥ 6.2 and GA was more than 14.55 % in accord with positive criteria at the same time, so it was concluded that the sensitivity was 96.7 %, than just used the FBG ≥ 7.0 mmol/L screening diabetes screening effi ciency by 35.4 %, and no obvious difference was found between specifi c degrees. Conclusion The joint test can improve the screening effi ciency. When FBG 7.0 mmol/L and ≥ 6.2 mmol/L and GA ≥ 14.55 %, OGTT is necessary adopted as a screening test to verify the diagnosis of diabetes." @default.
• W2349205760 created "2016-06-24" @default.
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• W2349205760 date "2014-01-01" @default.
• W2349205760 modified "2023-09-23" @default.
• W2349205760 title "Study on the Application Value of Fasting Blood Glucose and Glycosylated Serum Albumin in Screening Test Investigation for Type 2 Diabetes Mellitus" @default.
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