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- W2349206077 abstract "OBJECTIVE:To explore the possible mechanism of aloe gel on promote healing of injury in doxorubicin induced extravasation injury tissue in rats.METHODS:Forty five SD rats with extravasation injury model were randomly divided into NS group,magnesium sulfate group and aloe gel group.The healing rate and the degree of extravasation injury were compared,and after 1,4,7,11 and 18 days with different controls,the contents of TNF-α,IL-1β and IL-8 in the wound tissues were measured by ELISA.RESULTS:Aloe gel group can reduce the degree of injury,The wound healing rate of aloe gel group was signficantly higer than NS group(P0.05).Eighty days after treatment inthree groups of healing rates were(38.20±7.10)%,(63.76±17.24)%,(65.84±16.21)%.The contents of TNF-α,IL-1β and IL-8 of aloe gel group was obviously lower than those in NS group(P0.05).The differencere were significant compared NS group.Eighty days after treament in two groups of TNF-α,IL-1β and IL-8 contents were(14.55±3.13),(19.63±4.56),(9.86±2.78),(13.81±2.57),(5.56±1.46),(9.01±4.05) ng/L.CONCLUSIONS:Aloe gel can significantly reduce the extravasation injury and promote healing.The mechanism of the findings is associated with inhibit contents of TNF-α,IL-1β and IL-8 in extravasation injury tissue." @default.
- W2349206077 created "2016-06-24" @default.
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- W2349206077 date "2012-01-01" @default.
- W2349206077 modified "2023-09-27" @default.
- W2349206077 title "Effects and mechanism of aloe gel on doxorubicin induced extravasation injury tissue in rats" @default.
- W2349206077 hasPublicationYear "2012" @default.
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