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- W2349206683 abstract "Objective:To explore the renoprotective effect of L-arginine on streptozotocin-induced diabetic rats and its potential mechanism.Methods:Diabetic models were induced by intraperitoneal injection of streptozotocin STZ in r+ats.Models were randomly divided into two groups:DM group(non-treated diabetic model rats)and L-Arg group(diabetic model rats treated with L-arginine after 4 weeks).The normal non-diabetic rats were as the control group.The excretion of urinary albumin excretion rate(UAER),serum creatinine(SCr) and serum urea nitrogen(BUN)were detected after 8 weeks.Morphological changes of kidney were observed by optics microscope.The levels of nitric oxide(NO),the activity of superoxide dismutase(SOD)and malondialdehyde(MDA) in serum and renal cortex were detected;kidney mitochondrial membrane potential and mitochondrial swelling were measured in the different groups. Results:Compared with DM group,the excretion of UAER,SCr and BUN in L-Arg group were significantly decreased(P0.05),while the abnormal pathological changes were improved;the levels of NO and the activity of SOD in L-Arg group were also significantly increased(P0.01,P0.05),the levels of MDA were significantly reduced(P0.05);the kidney mitochondrial membrane potential was significantly elevated(P0.05) and mitochondrial swelling was reinforced. Conclusion:L-arginine protects the kidneys during diabetic model rats possibly by increasing the levels of NO and improving the function of mitochondria." @default.
- W2349206683 created "2016-06-24" @default.
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- W2349206683 date "2010-01-01" @default.
- W2349206683 modified "2023-09-24" @default.
- W2349206683 title "Protective effect of L-arginine on the kidney of diabetic rats" @default.
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