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- W2349207746 abstract "Objective To study the specific killing effect of arsenic trioxide-loaded albumin immuno-nanospheres [As 2O 3-(HAS-NS)-BDI-1] targeted with monoclonal antibody BDI-1 on bladder tumor cells BIU-87. Methods Covalent bond of As 2O 3-(HAS-NS)-BDI-1 was identified by SDS-PAGE reduction electrophoresis.The 3H-TDR incorporation methods were used to determine the specific killing activity of As 2O 3-(HAS-NS)-BDI-1 in vitro.Cell apoptosis and cycles were observed by FCM. Results The As 2O 3-(HAS-NS)-BDI-1 section yielded two bands on the SDS-PAGE reduction electrophoresis. 3H-TDR incorporation showed the specific killing activity of As 2O 3-(HAS-NS)-BDI-1 on bladder tumor cells.Cell cycle analysis showed that G0/G1 phase cell percentage decreased and G2/M phase cell percentage increased remarkably.Sub-G1 phase cells percentage increased to 18.4% at 24 h. Conclusions As 2O 3-(HAS-NS)-BDI-1 might specifically bind against bladder tumor cell BIU-87 and show high activity of killing bladder tumor cells." @default.
- W2349207746 created "2016-06-24" @default.
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- W2349207746 date "2004-01-01" @default.
- W2349207746 modified "2023-09-27" @default.
- W2349207746 title "Specific killing effect of arsenic trioxide-loaded albumin immuno-nanospheres on bladder tumor cells in vitro" @default.
- W2349207746 hasPublicationYear "2004" @default.
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