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- W2349219796 abstract "Objective:To investigate relationship between deposition amount and time of breviscapine common gel and solid lipid nanoparticle(SLN) gel in mice abdominal skin,and their topical pharmacokinetic of transdermal drug delivery.To investigate mechanism of SLN gel in enhancing breviscapine to penetrate into skin.Method:To set up an assaying methodology of breviscapine deposition amount in skin and compare accumulation deposition amount of breviscapine in skin between common gel and SLN gel,pharmacokinetics parameters were fitted by DAS software,in order to discuss topical pharmacokinetic of these two gels.Result:Within 24 h,per unit area deposition amount of breviscapine in skin of common gel were 1.73 times more than SLN gel;Dermatopharmacokinetic process of SLN gel and common gel were fitted with tow-compartment model and one-compartment model,respectively,AUC0-24 were 17.804,24.675 mg·L-1·h and T1/2 were 10.855,15.534 h,respectively.Conclusion:Transdermal degree and speed of SLN gel were greater and faster than common gel,which showed that SLN gel had function to enhance drug to penetrate into skin." @default.
- W2349219796 created "2016-06-24" @default.
- W2349219796 creator A5057569595 @default.
- W2349219796 date "2013-01-01" @default.
- W2349219796 modified "2023-09-23" @default.
- W2349219796 title "Transdermal Test and Topical Skin Pharmacokinetic Investigation of Breviscapine Lipid Carrier Gel in Mice" @default.
- W2349219796 hasPublicationYear "2013" @default.
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