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- W2349223529 abstract "AIM:This study was to investigate the expression and significance of Bmi-1 in colorectal carcinoma (CRC),and to explore the effect of Bmi-1 on Ki67 expression in human CRC.METHODS:The samples from sixty CRC,thirty adenomas and twenty normal colorectal mucosal tissues were used in this study. The expression of Bmi-1 protein was detected by immunohistochemistry. The clinicopathological features and survival rate of patients were also analyzed.RESULTS:The overexpression of Bmi-1 was respectively 25.0%,6.7%and 0% in CRC and adenomas as well as normal colorectal mucosal tissues. The results showed that the expression of Bim-1 was significantly higher in CRC,compared with that in adenomas and normal colorectal mucosal tissues (P0.05). The overexpression of Bmi-1 protein in CRC was obviously associated with distant metastasis and TNM stage (P0.05),but not with gender,age,tumor size,tumor site,histological type,differentiation degree and lymph node metastasis (P0.05). Kaplan-Meier survival analysis showed that the overexpression of Bmi-1 reduced significantly survival of CRC patients (P0.05). No statistical relation between expression of Bmi-1 and Ki67 in CRC was observed.CONCLUSION:The overexpression of Bmi-1 protein is significantly correlated with tumorigenesis,metastasis and prognosis of CRC. Bmi-1 might be regarded as a parameter in evaluating prognosis of CRC." @default.
- W2349223529 created "2016-06-24" @default.
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- W2349223529 date "2009-01-01" @default.
- W2349223529 modified "2023-09-23" @default.
- W2349223529 title "Expression and clinical significance of Bmi-1 in colorectal cancer" @default.
- W2349223529 hasPublicationYear "2009" @default.
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