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- W2349229583 abstract "Objective To study the proliferation-inhibitng and apoptosis-inducing effects of 23-hydroxy betulinic acid(23-HBA) on human microcapillary endothelial cells(HMEC).Methods The effect of 23-HBA on in vitro proliferation of HMEC was examined by SRB assay.The effect of 23-HBA on the cell cycle and apoptosis were analyzed by flow cytometry.Results The proliferation of HMEC was inhibited significantly by 23-HBA with IC50 being 40.44μg/ml.Apoptosis peak was also shown by flow cytometry.The percentage of cell apoptosis increased with the increase of the drug concentration,and the increase rate was significantly higher than that of the control cell group.The content of cells increased in S phase and decreased in G2/M phase.Conclusion 23-HBA can inhibit HMEC proliferation and induce apoptosis,could be developed as an anti-angiogenic drug." @default.
- W2349229583 created "2016-06-24" @default.
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- W2349229583 date "2007-01-01" @default.
- W2349229583 modified "2023-09-25" @default.
- W2349229583 title "Proliferation Inhibition and Apoptosis Induction of HMEC Cells by 23-HBA" @default.
- W2349229583 hasPublicationYear "2007" @default.
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