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- W2349249697 abstract "OBJECTIVE To establish the 6th international standard for unfractionated heparin and to develop an international collaborative study.METHODS Six candidate unfractionated heparin samples(code: T,W,V,X,Y,Z)were assayed against the 5th International Standard(97/578).National institute for the control of pharmaceutical biological products used five different methods in this study: anti-Xa chromogenic assay,anti-IIa chromogenic assay,whole rabbit blood of Chinese Pharmacopoeia(CHP),clot-based sheep plasma assay of European Pharmacopoeia(EP) and clot-based sheep plasma of US Pharmacopoeia(USP).RESULTS The data from our lab were adopted all to calculate the potency of the 6th international standard for unfractionated heparin.CONCLUSION National institute for biological standards and control analyzed the date from 36 laboratories.Candidate W(07/328) gave the lowest range of intra-and inter-laboratory variation.It is therefore recommended to be the 6th international standard for unfractionated heparin with an assigned value of 2 145 IU·ampoule-1 obtained from all assay methods." @default.
- W2349249697 created "2016-06-24" @default.
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- W2349249697 date "2010-01-01" @default.
- W2349249697 modified "2023-10-12" @default.
- W2349249697 title "International Collaborative Study on Developing the 6th International Standard for Unfractionated Heparin" @default.
- W2349249697 hasPublicationYear "2010" @default.
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