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- W2349252902 abstract "This paper presents the results of a study of 3 families with a slow β chainvariant found in Szechuan, Hubei and Jiangxi Provinces of China. Seven membersof these 3 families are all heterozygous for the abnormal hemoglobin gene. Accordingto its electrophoretic mobility, the abnormal hemoglobin was identified as G type hemoglobin. The amount of abnormal hemoglobin of these 3 propositi are 27.0%,32.3% and 36.5% respectively. The structural analyses of the variant (including globin chain separation, trypticdigestion of the aminoethylated β chain and finger-printing of the tryptic digest, aswell as amino acid composition and sequence analyses of the abnormal peptide) indicatedthat its β 22 glutamic acid is replaced by glycine, and hence it is named Hb G Taipei(β 22 (B4) Glu→Gly). Hb G Taipei distributed over the provinces along both sides of Huanghe (YellowRiver), China. They were found only in Chinese. Although these patients gaveno clinical symptoms, the study is significant to understanding of the occurrence ofmutation and it's geographical distribution. The application of the DABITC/PITC double-coupling method to the determi-nation of the amino acid sequence of abnormal peptides is discussed. It seems to usthat this micro-sequencing method has the advantage of being economical, rapid andaccurate. It is therefore worthy of wider application." @default.
- W2349252902 created "2016-06-24" @default.
- W2349252902 creator A5060570981 @default.
- W2349252902 date "1983-01-01" @default.
- W2349252902 modified "2023-09-27" @default.
- W2349252902 title "BIOCHEMICAL GENETICS OF HEMOGLOBIN G TAIPEI(AN ANALYSIS OF THREE PEDIGREES)" @default.
- W2349252902 hasPublicationYear "1983" @default.
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