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- W2349256904 abstract "Objective To investigate the role of Hepatocyte growth factor(HGF) in chronic liver allograft dysfunction in rats after orthotopic liver transplantation.Methods DA(RT1a)rats and Lewis(RT1l)rats were used as donors and receptors,respectively.All rats were injected tacrolimus at dose of 0.1mg/kg.day for 5 days post-transplantation.Treated group received injections of HGF(1 mg/kg,b.i.w) from 10 days to 90 days post-transplantation.Control group received the same dose of phosphate-buffer saline,the injected time was the same with treated group.The change of TNF-α in blood serum was measured with enzyme linked immunosorbent assay(ELISA).Results The mean survival rate of treated group was much higher than that of control group(P0.001).The grade of liver injures in treated group after transplantation was less than that of control group.The content of total bilirubin(TB) and alanine aminotransferase(ALT) in treated group was both significantly lower than that of control group(P0.01).The concentration of TNF-α in the serum of treated group decreased obviously compared with the control group(P0.01). Conclusion HGF contributes to the prevention of chronic liver-allograft dysfunction through its potent anti-inflammatory action,and it may become a novel treatment for chronic liver-allograft dysfunction." @default.
- W2349256904 created "2016-06-24" @default.
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- W2349256904 date "2010-01-01" @default.
- W2349256904 modified "2023-09-27" @default.
- W2349256904 title "Hepatocyte Growth Factor Preventing Chronic Allograft Dysfunction in Liver-Transplanted Rats" @default.
- W2349256904 hasPublicationYear "2010" @default.
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