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- W2349277569 abstract "Objective To evaluate the relationship between transforming growth factor β1(TGF-β1) and soft meninges fibrosis with response to thrombin in rats and to discuss the mechanism of communicating hydrocephalus following subarachnoid hemorrhage(SAH). Methods Thrombin was infused into subarachnoid space via foramen magnum of rats. TGF-β1 in cerebrospinal fluid(CSF) was measured by ELISA and the thickness of meningina collagen fibers was analysed by micrograph collection and analysis System after ld,10d and 20d respectively. Results The concentration of TGF-β1 was 239.02±129.40pg/ml(P0.05),309.07±57.30pg/ml(P0.05) and 283.16±128.87pg/ml(P0.05) respectively. There were statistically significant differences as compared with controls on every time point. The average thickness of meningina fibril was 3.68~0.43μm,4.29±0.52μm and 5.57±-0.77μm respectively and the difference had statistical significance between the latter two groups(P0.05). Conclusion It had been verificated that thrombin of suitable dosage infused in subarachnoid space could induce TGF-β1 to over-express in subarachnoid space and lead to hyperplasia of soft meninges fibril morphologically. So it could be presumed that thrombin may be an important mediating factor that leads to communicating hydrocephalus following SAH." @default.
- W2349277569 created "2016-06-24" @default.
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- W2349277569 date "2008-01-01" @default.
- W2349277569 modified "2023-09-24" @default.
- W2349277569 title "Association between transforming growth factor β_1 and soft meninges fibrosis with response to thrombin in rats" @default.
- W2349277569 hasPublicationYear "2008" @default.
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