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• W2349289944 abstract "Aim To illustrate the reason and significance of upregulation of cAMP-PDE activity in the lung of asthmatic rats, we studied the pulmonary function and phosphodiesterase (PDE) activity and IL-4 level in the lung tissue of model rats compared with the control rats, and observed the effects of the classical phosphodiesterase 4 inhibitor rolipram. Methods Ovalbumin sensitized and challenged rats were used as asthmatic model. Aerosol antigen induced inflammatory changes in bronchoalvelar lavegar fluid and peripheral blood were investigated. Dynamic lung compliance and pulmonary resistance were determined using a single chamber whole body plethysmogranph. Lung interleukin (IL)-4 level was determined by ELISA. cAMP-PDE and PDE4 activity were determined by HPLC. Results The cAMP-PDE and PDE4 activity, IL-4 level and total cell counts and eosinophil counts in BALF and peripheral blood in lungs of repeatedly OA challenged and sensitized rats were singnificantly increased than those in the control rats(P0.05). Meanwhile, dynamic lung compliance was singnificantly decreased and pulmonary resistance singnificantly increased. Rolipram(1 mg·kg~ -1 , po) increased dynamic lung compliance and decreased pulmonary resistance of OA sensitized and challenged rats significantly (P0.05). Rolipram significantly decreased the increased cAMP-PDE and PDE4 activity in lungs of repeatedly OA challenged and sensitized rats. Rolipram(0.3 mg·kg~ -1 , po) and rolipram(1 mg·kg~ -1 , po) singnificantly decreased the increased IL-4 level of repeatedly OA challenged and sensitized rats (P0.05). Rolipram markedly reduced total cell counts and eosinophil counts in BALF and peripheral blood of OA challenged and sensitized rats (P0.05). Spearman correlation analysis showed that cAMP-PDE activity, primarily due to PDE4 activity in lungs of repeatedly OA challenged and sensitized rats had statistically significant correlation with the IL-4 level (P0.05). Conclusion Rolipram significantly increased dynamic lung compliance and decreased pulmonary resistance, decreased the increased cAMP-PDE activity and IL-4 level in lungs of repeatedly OA challenged and sensitized rats. Moreover, cAMP-PDE activity or PDE4 activity had correlation with the IL-4 level." @default.
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• W2349289944 date "2006-01-01" @default.
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• W2349289944 title "The effects of rolipram on PDE activity and IL-4 level in the lung tissue of ovalbumin sensitized and repeatedly challenged rats" @default.
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