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- W2349307553 abstract "In order to confirm the antitumor effect of Cordyceps militaris cordycepin,inhibitive effects of cordycepin on human breast cancer cell MCF-7 and S 180-bearing mice were investigated. The proliferation and apoptosis of MCF-7 cells were measured using methyl thiazolyl tetrazolium( MTT) and flow cytometry. The results showed that cordycepin with mass concentrations ranging from 0. 1 to 5. 0 g /L could inhibit proliferation of MCF-7 cells significantly and the inhibition was in a time-and dose-dependent manner. After treatment with 0. 8 g /L cordycepin for 24,48 and 72 h,the growth inhibition rate of MCF-7 cells was 32. 6%,53. 3% and 87. 6% respectively,and the apoptosis rate of MCF-7 cells was 8. 65%,14. 20% and 26. 30% respectively. Moreover,the proportion of cells at G0 to G1 phases was increased significantly after treatment for 72 h. The growth of S 180 sarcomas in mice was extremely significantly inhibited( P 0. 01) after treatment with high,medium and low dosages [90,60 and 30 mg /( kg·d) ] of cordycepin. The inhibition rate was 64. 33%,44. 59% and 32. 48% respectively,which was dose-dependent as well. Medium and low dosages of cordycepin could increase spleen index and thymus index of S 180-bearing mice. These results confirmed that cordycepin can effectively inhibit the proliferation of MCF-7 cells and the growth of S 180 sarcoma and increase the immunity of mice." @default.
- W2349307553 created "2016-06-24" @default.
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- W2349307553 date "2013-01-01" @default.
- W2349307553 modified "2023-09-26" @default.
- W2349307553 title "Inhibitory Effect of Cordycepin on Human Breast Cancer Cell MCF-7 and S_(180) Sarcoma in Mice" @default.
- W2349307553 hasPublicationYear "2013" @default.
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