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- W2349352521 abstract "In previous study, the malignant transformation of Syrian hamster embryo(SHE) cell induced by cyclophosphamde(CP), following the formation of fibroblast sarcoma, had been identified. In this study, the molecular characters of the transformation were investigated by molecular hybridization, DNA sequencing and RTPCR. The study indicated that not only cmyc oncogene was activated by amplification, but also both Haras and Kiras oncogene had been mutated.The mutation of Haras oncogene fragment(207 bp) had been identified. The results showed that a 35 base substitution occurred. Most of the substitution appeared in the 3rd position of codon, only 2 in the 1st position. But only the GT transvertion of 3 rd base of codon 67 caused methionine to be substituted by isoleucine. Other base replacement did not alter the coded amino acid. The results also showed that there was no site specificity in Haras mutation. The mutation of p53 tumor suppressor gene had also been identified. The results show that the mutation may belong to point mutation. Therefore, the activation of cmyc, Haras, Kiras oncogene and inactivation or other changes of p53 tumor suppressor gene by mutation, along with their cooperation, may be the molecular mechanism of the malignant transformation of SHE cell induced by CP." @default.
- W2349352521 created "2016-06-24" @default.
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- W2349352521 date "1998-01-01" @default.
- W2349352521 modified "2023-09-25" @default.
- W2349352521 title "Molecular biological characters of malignant transformation of Syrian hamster embryo cell induced by cyclophosphamide" @default.
- W2349352521 hasPublicationYear "1998" @default.
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