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- W2349360206 abstract "Objective:To explore the effect of de novo methylation of gene promoter regions on the growth of gastric cancer.Methods: H-ras promoter regions of MGC-803 cells were methylated by SAM,cells growth status was evaluated by MTT assay,the methylation of H-ras promoter regions were detected by MSP and the expression of H-RAS proteins were determined by cell immunofluorescence.Results: H-ras promoter regions in gastric cancer cells were methylated after treated by SAM.Compared with the control group,gastric cancer cells MGC-803 treated by SAM obviously grew slowly and difference was considered statistically significant(P0.05),the expressions of H-RAS proteins were obviously decreased,and difference was considered statistically significant(P0.05).Conclusion: SAM could make the promoter of the oncongene H-ras remethylated in gastric cancer cell MGC-803,thus decreasing the expressions of H-RAS proteins,and significantly inhibiting the growth of tumor cells-an indication of its function in treatment of cancer." @default.
- W2349360206 created "2016-06-24" @default.
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- W2349360206 date "2011-01-01" @default.
- W2349360206 modified "2023-09-28" @default.
- W2349360206 title "Inhibition of gastric cancer cell by de novo methylated in H-ras gene promoter region" @default.
- W2349360206 hasPublicationYear "2011" @default.
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