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- W2349361397 abstract "Objective To recognize characteristic of HSV glycoprotein epitopes thoroughly and provide subunit or genetic engineering vaccines with more oligo-peptide immunogens in support. Methods Screened a 12-mer phage peptide library for 4 rounds by using a HSV type-common McAb against HSV glycoprotein c(gC) as selective molecule, which has strong animal protective activity. The results was confirmed by ELISA. 14 positive clones was selected randomly to sequence. Sequences alignment and blocking test were achieved. Results Our study reveals that mode of the sequences of the selected phage clones from the final eluate are highly homologous. High similarity is found in the region-SG(L)RHII- and its flanking sequence -AK-, -VW-, which contains 3 amino acids identical to those of the natural HSV gC. Phage containing this motif can react with the McAb specifically and can obviously block the reaction of mAb 1A12 and the natural HSV antigen. Conclusion The results imply that the motif selected could mimic the epitope on gC nd may be a substitute antigen of gC. This strategy provides the potential for preparing more effective epitope vaccine instead of whole protein and a new approach for developing epitope-specific diagnostic reagents." @default.
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- W2349361397 date "2002-01-01" @default.
- W2349361397 modified "2023-09-23" @default.
- W2349361397 title "Screening of HSV glycoprotein C mimotope binding to McAb 1A12" @default.
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