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- W2349366913 abstract "OBJECTIVE An RP-HPLC method was established for determination of the concentration of Clarithromycin in human plasma.METHODS The alkalized plasma sample was first extracted with n-hexane-dichloromethane-isopropyl alcohol(65:32:3),condensed by evaporation of organic layer,and then back extracted with n-hexane before injecting.The separation was carried out on a column of Kromasil C18(150 mm×4.6 mm,5 μm) with the mobile phase of acetonitrile-50 mmol·L-1 phosphate buffer solution(46:54,pH6.9).The flow rate was 1.0 ml·min-1,the column temperature was 40℃,and the detection wavelength was 210 nm.RESULTS A good linearity was obtained in the concentration range of 0.156-4.980 μg·ml-1(r=0.9997).The detection limit was 0.019 μg·ml-1 in plasma.The average extraction recovery was 82.0%.The RSD within-day and between-day were less than 2.0% and 2.5%,respectively.CONCLUSION The method is rapid and accurate for the determination of Clarithromycin in human plasma.It is suitable for the pharmacokinetic studies of Clarithromycin." @default.
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- W2349366913 date "2007-01-01" @default.
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- W2349366913 title "Determination of Clarithromycin in human plasma by RP-HPLC" @default.
- W2349366913 hasPublicationYear "2007" @default.
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