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- W2349375635 abstract "Objective:To establish an RP-HPLC method for the determination of rivastigmine capsules and its related substances.Methods:The separation was performed on a Hypersil BDS C18(250 mm×4.6 mm,5 μm) column,with the mobile phase consisting of methanol-0.05 mol·L-1 sodium hydrogen phosphate solution(58∶42,adjusted to pH 8.45 with phosphate acid);The flow rate was 1.0 mL· min-1,the detection wavelength at 214 nm,the column temperature was 40 ℃.Results:Rivastigmine and its related substances were completely separated by the method with a good linear range of 23.6-447.1 μg· mL-1(r=0.9997);the average recovery(n=9) was 99.3%;the limit of the detection was 0.3 ng.The related substances met the quality requirements in samples.Conclusion:The method is simple,sensitive,accurate and specific.It can be used for quality control of rivastigmine capsules." @default.
- W2349375635 created "2016-06-24" @default.
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- W2349375635 date "2011-01-01" @default.
- W2349375635 modified "2023-09-22" @default.
- W2349375635 title "RP-HPLC determination of rivastigmine capsules and its related substances" @default.
- W2349375635 hasPublicationYear "2011" @default.
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