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- W2349390238 abstract "The effects of pentachlorophenol (PCP) on Cyprinus Carpios lymphocyte activity, lymphocyte membrane integrity and erythrocytes hemolysis were examined using the MTT assay, the release of the lactate dehydro-(genase) (LDH) and the hemoglobin release respectively in vitro. The results showed that lymphocyte activity had no remarkable response to PCP in all test concentrations(2.50—1000.00μg·l~(-1)). But the membrane damage was found in 500.00 μg·l~(-1) and 1000.00 μg·l~(-1) groups, and the significant release of LDH was observed. The release of LDH increased with exposure time prolonging and exposure concentration increasing. The results also showed that PCP didn't change the release of hemoglobin from erythrocytes. But the release of hemoglobin was affected significantly by synergistic effects of PCP and Dibenzoanthracene and the (release) of hemoglobin increased with the concentration of the mixture of PCP and Dibenzoanthracene (increasing). It is a conclusion in the present study that there is obvious cytotoxicity of PCP in lower (concentration) to blood cells of Cyprinus Carpios. The damage of lymphocyte membrane is more sensitive than lymphocyte activity and erythrocytes hemolysis to lower concentration of PCP. It is suggested that the release of LDH as a biomarker could be used to monitor and evaluate the contamination of PCP in aquatic ecosystem." @default.
- W2349390238 created "2016-06-24" @default.
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- W2349390238 date "2005-01-01" @default.
- W2349390238 modified "2023-09-25" @default.
- W2349390238 title "CYTOTOXICITY TESTING OF PENTACHLOROPHENOL IN LOWER CONCENTRATION TO BLOOD CELLS OF CYPRINUSCARPIOS IN VITRO" @default.
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