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- W2349394621 abstract "Objective To investigate the clinical outcomes of chemotherapy of cerebral gliomas guided by chemosensitivity testing in vitro.Methods The response of malignant brain tumor to chemotherapeutic agents was determined with ATP bioluminescence(ATP-TCA) assay in vitro in 47 cases underwent subtotal resection of gliomas,who received chemotherapy on the bases of chemosensitivity test(group A).The clinical outcomes in group A were compared to those in the patients (group B) underwent conventioal chemotherapy and with the similar conditions to group A. Results Cytotocixity assay was performed for 47 malignant brain tumor specimens,of which 45 specimens succeeded with the success rate of 95.7%. Total conformity between in vitro and clinical results was 85.8%.The sensitivity,specificity,positive and negative predictive value of in vitro assay were 79.4%,92.5%,90.6% and 76.1%,respectively.The patients of group A had complete response(CR) in 2 cases,partial response(PR) in 5 cases,stable disease(SD) in 14 cases,and progerssive disease(PD) in 9 cases with the response rate (CR+PR) of 23.3% and disease control rate (CR+PR+SD) of 70.0%.The patients of group B had no CR,PR only in 2 cases,SD in 13 cases,PD in 20 cases with the response rate of 5.7% and disease control rate of 42.9% ,which were significantly poorer than those in group A(P0.05). Conclusion ATP-TCA assay is of significance in screening the sensitive chemotherapeutic agents and taking individualized chemotherapy." @default.
- W2349394621 created "2016-06-24" @default.
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- W2349394621 date "2009-01-01" @default.
- W2349394621 modified "2023-09-24" @default.
- W2349394621 title "Chemotherapy of cerebral gliomas guided by chemosensitivity testing in vitro" @default.
- W2349394621 hasPublicationYear "2009" @default.
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