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- W2349401132 abstract "Objective: To investigate the influence of tranilast on cell cycle modulatory factors and proliferation response of vascular smooth muscle cells after balloon angioplasty.Methods: Thirty SD rats were randomly divided into three groups as sham operation group,operation group(28 d) and tranilast group(28 d).Baloon-induced endothelium denudation at thoracic aortae were performed in both the operation group and tranilast group.Drugs were administered by gavage.Aortic tissue were harvested at day 28 after injury.Results: ① Neointima formation was apparent in the arteries from the operation group and was reduced much more in the tranilast group(P0.01),while no neointima formation was seen in the sham operation group.② Immunohistochemistry staining revealed that P27 protein expressions were weak in the the neointima of the operation group and and were significantly increased by tranilast.In the operation group,the neointima PCNA was strongly expressed,while the expression became week in the tranilast group(P0.01).③ Flow cytometry show that in the operation group,the percentage of S phase of smooth muscle cells was high but declined in the tranilast group.Conclusion: Tranilast surpressed neointima forming after artery injury through up-regulation of P27,suggesting that tranilast are useful in treating vascular proliferate diseases such as atherosclerosis and post-PTCA restenosis." @default.
- W2349401132 created "2016-06-24" @default.
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- W2349401132 date "2008-01-01" @default.
- W2349401132 modified "2023-09-23" @default.
- W2349401132 title "Tranilast Inhibits Vascular Smooth Muscle Cell Growth and Intimal Hyperplasia by Induction of P27" @default.
- W2349401132 hasPublicationYear "2008" @default.
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