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- W2349407130 abstract "AIM Investigating the effects of corticosterone on the voltage gated calcium channel and synaptic transmission in the cultured hippocampal neurons to clarify the reasonable mech anisms. METHODS The cultured hippocampal neurons from neonatal rats were served as preparation. The effect of corticosterone on the voltage gated calcium channel and synaptic activity was observed by using whole cell recording technique just after corticosterone was administrated by a pressure ejector. RESULTS The amplitudes of voltage gated calcium currents were increased (14±8)%, (41±13)% and (58±9)%, when 1, 10 and 100 μmol·L -1 of corticosterone was applied, respectively. The potentiation was concentration dependent, but voltage independent. The characteristics of calcium channel were not influenced. Corticosterone (100 μmol·L -1 ) increased the frequency of spontaneous synaptic activity to about 4 fold of the control. Excitatory synaptic currents with low frequency 〔(4.6±1.0)Hz〕 and small amplitude 〔(0.18±0.09)nA〕 could be still elicited by corticosterone in the presence of tetrodotoxin. CONCLUSION Corticosterone facilitated the voltage gated calcium current and the synaptic transmission in the cultured hippocampal neurons. The immediate potentiation excluded the possibility that the gene modulation of corticosterone was involved." @default.
- W2349407130 created "2016-06-24" @default.
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- W2349407130 date "2002-01-01" @default.
- W2349407130 modified "2023-09-25" @default.
- W2349407130 title "Effects of corticosterone on voltage-gated calcium channel and spontaneous synaptic activities in cultured hippocampal neurons from neonatal rat" @default.
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