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- W2349422476 abstract "Objective To research the equipments and the route for automated synthesis and preliminary clinical application of [ N -methyl- 11 C] choline ( 11 C-choline). Methods 11 C-choline was produced on-line with column-method. The biodistribution was studied on nude mice bearing lung adenocarcinoma. The PET imaging was performed with Walker 256 on rats. The results of 11 C-choline were assessed and compared with that of 18 F-fluorodeoxyglucose (FDG) in 11 patients. Results The radiochemistry purity of the synthesized 11 C-choline was more than 99%,the synthesis yield was 95%. It took 5 min from 11 C-CHI_3 to 11 C-choline. The biodistribution of 11 C-choline was that most part of the activity was in the liver and intestine. Tumor/blood ratio increased from 0.9 to 6.9 within 5 min to 20 min after the injection of the agent. The clinical results showed that 11 C-choline detected 7/7 malignant lesions in 4 patients,and 18 F-FDG detected 3/7. 18 F-FDG gave false negative results to 4 of the 4 brain lesions. There was high uptake of 18 F-FDG in 7 benign lung lesions in 7 patients,and high uptake of 11 C-choline in only one lesion. Conclusion It is feasible for PET center to synthesize 11 C-choline with column-method because the method is high yielding,less time consuming and easy to perform." @default.
- W2349422476 created "2016-06-24" @default.
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- W2349422476 date "2004-01-01" @default.
- W2349422476 modified "2023-09-25" @default.
- W2349422476 title "Automated production and preliminary clinical application of ~(11)C-choline" @default.
- W2349422476 hasPublicationYear "2004" @default.
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