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- W2349424002 abstract "Objective To investigate the proliferation inhibition of hydroxycamptothecin(HCPT)-carrying microbubbles on human hepatoma SMMC-7721 cells using technique of ultrasound mediated drug release.Methods The SMMC-7721 cells were randomly divided into six groups as follows:HCPT-carrying microbubbles plus ultrasound,HCPT plus ultrasound,HCPT,HCPT-carrying microbubbles,blank microbubbles plus ultrasound,and control group.The cell growth inhibitory effect of each group was observed by MTT assay.Cell cycle distribution was analyzed using flow cytomertry(FCM).Apoptosis was ascertained by Annexin V-Fitc/PI and TUNEL methods.Results The growth of SMMC-7721 cell line was significantly inhibite by combining HCPT-carrying microbubbles and ultrasound.The cell inhibitory rate at 12 h,48 h,72 h was(49.56±1.57)%,(80.01±1.52)% and(91.41±0.64)%,respectively.The SMMC-7721 cells were effectively arrested in G0/G1 phase.The apoptosis rate at early term was found to reach(12.18±1.38)% by Annexin V-Fitc/PI assay.Brown-colored positive apoptotic cells were observed and the apoptosis rate at advanced term was found to reach(34.25±1.83)% with TUNEL method.Differences with other groups were significant.Conclusion The method of ultrasound irradiating HCPT-carrying microbubbles significantly inhibits the human hepatoma SMMC-7721 cells proliferation.Cell cycle arrest and apoptosis might be responsible for cells growth inhibition." @default.
- W2349424002 created "2016-06-24" @default.
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- W2349424002 date "2009-01-01" @default.
- W2349424002 modified "2023-09-24" @default.
- W2349424002 title "Ultrasound irradiating hydroxycamptothecin-carrying ultrasound microbubbles for proliferation inhibition of human hepatoma SMMC-7721 cells" @default.
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