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- W2349452014 abstract "AIM: To observe the effect of transplantation ofolfactory ensheathing cells seeded in directional collagen-heparin sulfate scaffold on spinal cord injury repairing. METHODS: Collagen-heparin sulfate scaffold with longitudinal, paralleled microtubules, was produced under freeze-drying condition. Olfactory ensheathing cells and this scaffold was compounded together to construct new type of nervous tissue engineering material, which was transplanted to repair 3 mm segmental rat spinal cord injury. Neurological observation, electrophysiological and morphological detection were performed 12 weeks after transplantation to explore the repairing effect. RESULTS: NF and GAP-43 double-labeled immunofluorescence, MBP immunofluorescence, toluidine staining and eletron-microscope observation all proved that the regenerated spinal nerve fiber successfully grew into this nervous tissue engineering material. BBB scoring and electrophysiological detection proved that part rats reacquired satisfactory motor function. CONCLUSION:Collagen-heparin sulfate scaffold compounded with olfactory ensheathing cells could be transplanted to repair spinal cord injury, which could promote the spinal axon regeneration." @default.
- W2349452014 created "2016-06-24" @default.
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- W2349452014 date "2008-01-01" @default.
- W2349452014 modified "2023-09-23" @default.
- W2349452014 title "Transplantation of olfactory ensheathing cells seeded in linearly oriented nerve guidance scaffolds promotes axon regeneration in spinal cord injury" @default.
- W2349452014 hasPublicationYear "2008" @default.
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