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- W2349455087 abstract "Objective To observe the effect of the recombinant human epidermal growth factor used in skin wound and its dose responds relationship.Methods The dorsal trauma model of rabbits was made.100 skin wounds were made on the back of 20 rabbits.Then the wounds were designed into experiment and control ones.The experiment wounds were subdivided into groups of high dosage rh-EGF(100μg/g),middle dosage rh-EGF(10μg/g),low dosage rh-EGF(0.5μg/g).The control wounds include isotonic saline group and EGF matrix group.The process of wound healing was observed.Mean healing time and healing area rate was calculated.Moreover,the dynamic analysis was performed at different times on wound OHP contents.Results The mean time of the rh-EGF wound healing groups was (14.7±0.67) d,(13.9±0.92)d,(12.8 ±0.99)d,P 0.05),respectively,the control groups was(15.5±0.85)d and(15.8±0.90)d(P 0.05).The wound healing was accelerated clearly in all wounds treated with rh-EGF,especially with high dosage rh-EGF.In the high dosage rh-EGF group,the re-epithelialization was faster and new granulation tissue was more than those of the control groups.Also,OHP content was increased in the rh-EGF groups.Conclusion External rh-EGF can shorten wound healing time,and dose responds relationship exists.High dosage rh-EGF promote incision repair better." @default.
- W2349455087 created "2016-06-24" @default.
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- W2349455087 date "2011-01-01" @default.
- W2349455087 modified "2023-09-23" @default.
- W2349455087 title "Study on the effect of the recombinant human epidermal growth factor used in skin wound of rabbits and its dose responds relationship" @default.
- W2349455087 hasPublicationYear "2011" @default.
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