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- W2349493993 abstract "Objective To investigate the correlation of dynamic contrast-enhanced (DCE) MRI features with microvessel density (MVD) and vascular endothelial growth factor (VEGF) in non-small cell lung cancer(NSCLC).Methods Conventional MR imaging and dynamic contrast-enhanced scan in thirty-three patients with NSCLC confirmed by pathologyn were performed. MVD and VEGF were stained with immuno-histochemical technique in all cases. Some parameters of DCE MRI, including maximum slope(Smax) and time to peak(TTP) were put more analysis. The relationship between the results of DCE MRI (Smax and TTP) and that of immuno-histochemistry (MVD and VEGF) was analysed.Results The Smax of adeno carcinoma was higher than that of squamous cell carcinoma,but TTP was lower. The difference was obvious difference(t=3.22,P0.01 and Z=-2.795,P0.05 ).Adenocarcinoma and squamous cell carcinoma were of apparent difference in MVD or VEGF express levels (MVD:Adenocarcinoma 50.19±9.59,squamous cell carcinoma 33.16±5.65; t=6.34,P0.001;VEGF: Fisher’s exact test P=0.0150.05).Conclusion Parameters of DCE MRI, especially Smax and TTP, can reflect MVD and VEGF express levels in NSCLC. The Smax and TTP might be indexes for VEGF-related tumor angiogenesis ." @default.
- W2349493993 created "2016-06-24" @default.
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- W2349493993 date "2003-01-01" @default.
- W2349493993 modified "2023-09-24" @default.
- W2349493993 title "Tumor Angiogenesis and Dynamic Contrast-enhanced MR Imaging in Non-small Cell Lung Cancer:Imaging-Pathologic Correlation" @default.
- W2349493993 hasPublicationYear "2003" @default.
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