Matches in SemOpenAlex for { <https://semopenalex.org/work/W2349495451> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2349495451 abstract "【Objective】 An experiment was designed to detect the relationship between the content of 5-hydroxytryptamine(5-HT) in the media layer of pulmonary arterioles and the proliferation of pulmonary arterioles smooth muscle cells,with the purpose to clarify whether or not 5-HT transporter(5-HTT) was participated in the occurrence of pulmonary hypertension in broilers.【Method】Broilers at 20 day of age were randomly divided into non-disease inducing groups(intravenously injection of normal saline,including blank control group,Fluoxetine group,Citalopram group,30 fowls in each group) and disease inducing groups(intravenously injection of cellulose particles,including medicine blank control group,Fluoxetine group,Citalopram group,50 fowls in each group.).From day 21 on,the morbidity of pulmonary hypertension syndrome(PHS) of each group were recorded.Samples were randomly taken from each group on day 21,28,35 and 42,and the weight ratio between right ventricle and total ventricle(RV and TV) was determined.5-HT content in pulmonary arteriolar media layer was detected by using the immunohistochemical technique,and the proliferation conditions of smooth muscle cells in pulmonary arterioles was detected by argyrophilic nucleolar organizer region proteins staining method(AgNOR) and proliferating cell nuclear antigen(PCNA) staining method.【Result】PHS morbidity and RV/TV value of disease-inducing groups were significantly higher than that of non-disease inducing groups(P0.05).The 5-HT content in pulmonary arteriolar media was increased in disease-inducing groups,as well as the argyrophilic particles on the smooth muscle cells and the PCNA positive cells.Fluoxetine and Citalopram(both are 5-HTT inhibitors) significantly reduced the morbidity of PHS and 5-HT contents in pulmonary arteriolar media in broiler,and inhibited the proliferation of smooth muscle cells.There were no significant difference between the two medicines.【Conclusion】During the occurrence of pulmonary hypertension in broilers,the increasing of 5-HT content in pulmonary arteriolar smooth muscle cells which was mediated by 5-HTT resulted in the excessive proliferation of smooth muscle cells,leading to the occurrence of PHS.5-HTT is possibly a significant target molecular for the prevention and treatment of PHS in broilers." @default.
- W2349495451 created "2016-06-24" @default.
- W2349495451 creator A5052973478 @default.
- W2349495451 date "2012-01-01" @default.
- W2349495451 modified "2023-09-26" @default.
- W2349495451 title "Influence of 5-HT Transporter Inhibitors on the 5-HT Content and the Proliferation of Smooth Muscle Cells in Pulmonary Arteriolar Media in Broilers with Pulmonary Hypertension" @default.
- W2349495451 hasPublicationYear "2012" @default.
- W2349495451 type Work @default.
- W2349495451 sameAs 2349495451 @default.
- W2349495451 citedByCount "0" @default.
- W2349495451 crossrefType "journal-article" @default.
- W2349495451 hasAuthorship W2349495451A5052973478 @default.
- W2349495451 hasConcept C126322002 @default.
- W2349495451 hasConcept C134018914 @default.
- W2349495451 hasConcept C142724271 @default.
- W2349495451 hasConcept C170493617 @default.
- W2349495451 hasConcept C204232928 @default.
- W2349495451 hasConcept C2775864247 @default.
- W2349495451 hasConcept C2776134451 @default.
- W2349495451 hasConcept C2778921608 @default.
- W2349495451 hasConcept C2780930700 @default.
- W2349495451 hasConcept C34688535 @default.
- W2349495451 hasConcept C71924100 @default.
- W2349495451 hasConcept C74864618 @default.
- W2349495451 hasConcept C86803240 @default.
- W2349495451 hasConceptScore W2349495451C126322002 @default.
- W2349495451 hasConceptScore W2349495451C134018914 @default.
- W2349495451 hasConceptScore W2349495451C142724271 @default.
- W2349495451 hasConceptScore W2349495451C170493617 @default.
- W2349495451 hasConceptScore W2349495451C204232928 @default.
- W2349495451 hasConceptScore W2349495451C2775864247 @default.
- W2349495451 hasConceptScore W2349495451C2776134451 @default.
- W2349495451 hasConceptScore W2349495451C2778921608 @default.
- W2349495451 hasConceptScore W2349495451C2780930700 @default.
- W2349495451 hasConceptScore W2349495451C34688535 @default.
- W2349495451 hasConceptScore W2349495451C71924100 @default.
- W2349495451 hasConceptScore W2349495451C74864618 @default.
- W2349495451 hasConceptScore W2349495451C86803240 @default.
- W2349495451 hasLocation W23494954511 @default.
- W2349495451 hasOpenAccess W2349495451 @default.
- W2349495451 hasPrimaryLocation W23494954511 @default.
- W2349495451 hasRelatedWork W2002875212 @default.
- W2349495451 hasRelatedWork W2044684848 @default.
- W2349495451 hasRelatedWork W2351196822 @default.
- W2349495451 hasRelatedWork W2351773627 @default.
- W2349495451 hasRelatedWork W2355085985 @default.
- W2349495451 hasRelatedWork W2356543536 @default.
- W2349495451 hasRelatedWork W2358558496 @default.
- W2349495451 hasRelatedWork W2363351471 @default.
- W2349495451 hasRelatedWork W2364491540 @default.
- W2349495451 hasRelatedWork W2368834117 @default.
- W2349495451 hasRelatedWork W2370356898 @default.
- W2349495451 hasRelatedWork W2375022691 @default.
- W2349495451 hasRelatedWork W2380041018 @default.
- W2349495451 hasRelatedWork W2382256095 @default.
- W2349495451 hasRelatedWork W2382412918 @default.
- W2349495451 hasRelatedWork W2382477139 @default.
- W2349495451 hasRelatedWork W2390310201 @default.
- W2349495451 hasRelatedWork W2394445209 @default.
- W2349495451 hasRelatedWork W2394765739 @default.
- W2349495451 hasRelatedWork W2415577820 @default.
- W2349495451 isParatext "false" @default.
- W2349495451 isRetracted "false" @default.
- W2349495451 magId "2349495451" @default.
- W2349495451 workType "article" @default.