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• W2349520022 abstract "Objective To investigate the changes of polymorphnuclear neutrophil(PMN)adhesion molecule CD11b and serum soluble ICAM-1(sICAM-1),and therapeutic effects of Lactated Ringers,7.5%HTS and 20%Albumin on severely injured patients.Methods Sixty severely injured patients(ISS score 16 to 41)were divided into group with ISS≤25 and group with ISS25 groups.Each group was subdivided into LR,HTS and Albumin groups.CD11b and sICAM-1 were measured by using flow cytometry and ELISA,respectively.Results PMN CD11b and sICAM-1 were elevated 4 hours after trauma in all experimental groups(P0.05),CD11b and SICAM-1 were higher in the ISS group than in ISS≤25 group from 12 to 48 hours after trauma(P0.05),but were significantly lower in the HTS and Albumin groups than in the LR group from 24 to 48 hours(P0.05).The incidence of MODS and mortality in the ISS group was higher than in the ISS≤25 group,and lower in the Albumin and HTS groups than LR group(P0.05).Conclusion PMN CD11b and sICAM-1 expression,which may vary,depending on the type of resuscitation fluids used,are increased in severely injured patients and are related with the severity of trauma.Among the studied fluids,20% Albumin and 7.5% HTS can lead to lower expression of CD11b and sICAM-1,and lower incidence rate of MODS and mortality than using Lactated Ringers alone." @default.
• W2349520022 created "2016-06-24" @default.
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• W2349520022 date "2004-01-01" @default.
• W2349520022 modified "2023-09-23" @default.
• W2349520022 title "Studies on expression of serum adhesion molecules and therapeutic effects of various resuscitation fluids on severely injured patients" @default.
• W2349520022 hasPublicationYear "2004" @default.
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