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- W2349530963 abstract "Objective To investigate the effects of proteasome inhibitor MG-132 on internening K562 cell apoptosis at different times. Methods MTT assay was used to observe the effect of K562 cell proliferation after 16μmol/L MG-132 treatment at different time points (0,24,48,72 and 96 h); immunohistochemistry was employed to detect the expressions of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and glucocorticoid receptor (GR),respectively,and flowcytometry was applied to detect the K562 cell apoptosis. Results MTT:Following MG-132 intervention at different time points,the inhibition rate of K562 cell proliferation K562 cell exhibited time dependence,of which the results in the experiment groups were markedly higher than those in the control group (P0.05 each),with its peak,(63.33±1.52)% at 72 h. Immunohistochemistry:After MG-132 treatment,the expression levels of NF-κB and GR in the K562 cells showed time dependence. Compared with the control group,the NF-κB expression in experiment groups was down-regulated,with its nadir,(51.15±1.64)% at 96 h (P0.05). As compared to the control group,the GR expression in experiment groups was up-regulated,with its peak,(89.21±3.49)% at 72h (P0.05). Flowcytometry:After MG-132 treatment,the apoptosis rate of K562 cells were in a time-dependent manner,and the K562 cell apoptosis rate in test groups was higher than that in the control group,with its peak,(17.57±1.45)% at 72 h (P0.05). Conclusion MG-132 may induce K562 cell apoptosis and inhibition of proliferation by down-regulating the NF-κB expression and up-regulating the GR expression in a time-dependent manner." @default.
- W2349530963 created "2016-06-24" @default.
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- W2349530963 date "2009-01-01" @default.
- W2349530963 modified "2023-09-26" @default.
- W2349530963 title "Effect of proteasome inhibitor MG-132 on induction of K562 cell apoptosis at different times" @default.
- W2349530963 hasPublicationYear "2009" @default.
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