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- W2349532616 abstract "Objective To explore the clinical significance of detecting hepatitis B virus PreS 2 antigen and PreS 2 antibody.Methods HBVM,PreS 2 antigen and PreS 2 an-tibody of92serum samples were determined by ELISA,and the relationships of the re-sults of above tests were analyzed.Results The positive rate of the PreS 2 antigen in the HBsAg-positive group and HBeAg positive group were64.71%,96.97%respetively,and the positive groups were significantly higher than that in the negative group(P0.01).The corresponding rates beween PreS 2 antigen and HBsAg or HBeAg were73.91%,85.87%respectively.The positive rate of the PreS 2 antigen was lower than that of HB-sAg ,but higher than that of HBeAg .There was significant association between total de-tection rate of the PreS 2 antigen and HBeAg and HBsAg(P0.01),and there was signifi-cant difference between the fraction of discordance of the PreS 2 antigen and HBeAg.The positive rate of the PreS 2 antibody in the HBeAb-positive group(72.22%)was signif-icantly higher than that in the HBeAb-negative group (23.21%),The corresponding rate of the PreS 2 antibody with HBeAb was75%,with no significant difference between PreS 2 antibody and HBeAb.Conclu sions It is suggested that the PreS 2 antigen may be served as a sensitive marker for hepatitis B virus infection and replication.It is very important to diagnose premier infection and situation of replication of HBV,and to ob-serve the effect and prognosis of hepatitis B by detecting PreS 2 -Ag and PreS 2 -Ab con-tinually." @default.
- W2349532616 created "2016-06-24" @default.
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- W2349532616 date "2003-01-01" @default.
- W2349532616 modified "2023-09-25" @default.
- W2349532616 title "Clinical significance of detecting hepatitis B virus PreS_2 antigen and PreS_2 antibody" @default.
- W2349532616 hasPublicationYear "2003" @default.
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