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- W2349536366 abstract "Objective:To investigate the effect of different concentrations of leptin on the expression of CXCR4,MMP_9 and VEGF in trophoblasts of human first trimester gestation.Methods:24 hours after incubated the trophoblasts of first trimester gestation,the levels of CXCR4,MMP_9 and VEGF mRNA under the condition of different concentration leptin in primary trophoblasts by real-time PCR were determined.Results:CXCR4,MMP_9 and VEGF mRNA was higher treated by leptin than that without leptin(P0.01).After treated with 500 ng/ml,CXCR4 mRNA was 2 times higher,both MMP_9 and VEGF mRNA were 5 times higher than those without leptin.Conclusion:Leptin alone could increase the expression of CXCR4,MMP_9 and VEGF in trophoblasts.Human first trimester trophoblasts produced CXCR4,MMP_9 and VEGF,which may play important biological role in the normal human pregnancy,and contribute to the physiological pregnancy process." @default.
- W2349536366 created "2016-06-24" @default.
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- W2349536366 date "2006-01-01" @default.
- W2349536366 modified "2023-09-25" @default.
- W2349536366 title "Effect of leptin on the expression of CXCR4,MMP_9 and VEGF in trophoblasts of human first trimester gestation" @default.
- W2349536366 hasPublicationYear "2006" @default.
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