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- W2349541961 abstract "Hepatitis B virus (HBV)-specific CD8+ T lymphocytes (CTL) play a major role in the control and clearance of HBV infection. However, the majority of human leukocyte antigen (HLA) class I restricted epitopes have been defined in HBV genotypes A and D, but definitions are lacking in genotypes B and C, which are prevalent in China. In this study, the overlapping 9-mer peptide pools were used to screen and identify genotypes B- and C-derived HBcAg-specific T cell epitopes by HLA stabilization assays and in vitro re-folding assays. We identified a new epitope derived from a leucine to valine mutation at position 60 of the core protein (L60V). This epitope can elicit CTL responses in HLA-A2/Kb transgenic mice. The defined HBV epitope was further characterized by investigating specific CTL responses in HLA-A2 positive patients with acute and chronic hepatitis B, indicating that the T cell epitope was naturally processed. These findings will provide a basis for the analysis of CTL responses in patients with HBV infection." @default.
- W2349541961 created "2016-06-24" @default.
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- W2349541961 date "2010-01-01" @default.
- W2349541961 modified "2023-09-23" @default.
- W2349541961 title "Identification of an HLA-A2 restricted HBcAg-specific T cell epitope derived from HBV genotypes B and C" @default.
- W2349541961 hasPublicationYear "2010" @default.
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