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- W2349551451 abstract "[Objective]The effect of different buffer on the amount of IVM release from Zein tabletted microsphere encapsulating ivermectin(IVM)was studied in this paper;[Methods]Pertaining to condition of the stomach and small intestine of mouse in vivo,the release kinetics and dissolution rate of the drug from these tablets were studied in different buffers;[Results]The percentage of IVM release was 19.60±0.95% and 25.62±5.17% in 0.1mol/L HCl and disodium hydrogen phosphate-citric acid buffer(pH=2.2)for 2 hours,respectively(p0.05);while in 0.1mol/L HCl +0.32% pepsin(w/v),disodium hydrogen phosphate-citric acid buffer(pH=2.2)+0.075%pepsin(w/v)and disodium hydrogen phosphate-citric acid buffer(pH=2.2)+0.0375% pepsin(w/v)for 2 hours,the percentage of IVM release was 62.00±3.76%,74.18±8.26%,64.61±3.20%,respectively(p0.05);The IVM released 42.27% at 2 hours in 0.1mol/L HCl containing 5% stomach content(w/w),and reached 88.03% for another three hours in PBS containing 4% small intestine content(w/w);[Conclusion]Pepsin could accelerate the dissolution rate of IVM from both kinds of tablets." @default.
- W2349551451 created "2016-06-24" @default.
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- W2349551451 date "2008-01-01" @default.
- W2349551451 modified "2023-09-25" @default.
- W2349551451 title "Evaluation Releasing in Vitro of IVM Sustained-release Microsphere Tablets" @default.
- W2349551451 hasPublicationYear "2008" @default.
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