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- W2349559458 abstract "Objective To investigate if there needs limitation to iodide intake before thyroid scintigraphy with 99mTcO-4 by evaluating effect of a single dose of iodide intake on rat thyroid sodium/iodide symporter (NIS) protein expression. Methods Sprague Dawley (SD) rats were divided into 1 day group,7 day group and control group with 8 animals in each group. The animals in 1 day group and 7 day group were administered 2000 g NaI dissolved in normal saline through peritoneal injection,and animals in control group were given equal dose of normal saline. The animals in 1 day group and 7 day group were sacrificed on day 1 and day 7 after iodide was administrated,and thyroid was isolated to detect the NIS protein expression using Western blot and semi-quantitative analysis was done using optical density analysis. Results The NIS protein expressed in 1 day group was significantly lower than its expression level in 7 day group and control group (both P0.001),while there were no significant difference between control group and 7 day group (P0.05). Conclusion A single large dose of iodide intake can significantly decrease thyroid expression of NIS protein on 1 day after iodide was administrated,and expression of NIS protein can return to normal level 7 days later." @default.
- W2349559458 created "2016-06-24" @default.
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- W2349559458 date "2009-01-01" @default.
- W2349559458 modified "2023-09-23" @default.
- W2349559458 title "Effect of acute iodide administration on expression of sodium/iodide symporter protein in rat thyroid" @default.
- W2349559458 hasPublicationYear "2009" @default.
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