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- W2349569501 abstract "Objective To exporle the diagnostic value of thrombomodulin(TM),prothrombin fragment 1+2(F1+2) and D-dimer(D-D) for early disseminated intravascular coagulation(DIC) in children with infectious diseases.Methods D-D were examined in 58 suspected DIC cases with infectious diseases and 30 healthy children(group A) using enzyme-linked immunosorbent assay(ELISA).Platelet count(BPC),prothrombin time(PT),fibrin degradation products(FDP) and fibrinogen(Fg) were examined using routine methods.10 of the 58 cases developed into DIC that determined by ISTH scores.The 58 cases were divided into non-DIC group(group B) and DIC group(group C).TM,F1+2,D-D,BPC,PT,Fg and FDP were retrospectively analyzed and compared between group B and group C.Results 1.The TM and F1+2 were significantly higher in group C than those in group B and group A(P0.05).There was no significant difference between group A and group B.Whereas the D-D had no significant difference in three groups(P0.05).There was no significant difference in BPC,PT,FDP,Fg and the ISTH scores between group B and group C;2.The abnormal rate of TM and F1+2 were significantly higher in group C than those in group B.Whereas the abnormal rare of D-D,BPC,PT,FDP and Fg had no significant difference between group B and group C;3.The D-D in group C was significantly higher in DIC patients than in suspected DIC patients.Conclusion The detection of TM and F1+2 would be helpful to early diagnosis of DIC in children with infectious diseases and their specificity and sensitivity were high.D-D monitoring would be helpful to DIC diagnosis." @default.
- W2349569501 created "2016-06-24" @default.
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- W2349569501 date "2013-01-01" @default.
- W2349569501 modified "2023-09-27" @default.
- W2349569501 title "Diagnostic value of hemostatic molecular for early disseminated intravascular coagulation in children with infectious diseases" @default.
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