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- W2349569892 abstract "To investigate the change of ventricular beta2 adrenergic receptor(AR) mRNA levels and the effects of beta2 adrenergic blocker on ventricular fibrillation threshold(VFT) and ventricular effective refractory period(VERP) after myocardial infarction(MI).①Sixty Wistar rat models with MI were randomly divided into three groups:2,4 and 8 weeks groups after MI.Every group was randomly devided into four subgroups.The subgroups respectively were given beta2 adrenergic blocker ICI 118 551,beta1 adrenergic blocker atenolol,beta adrenergic blocker propranolol separately,VFT and VERP were measured.②Using the reverse transcription PCR, ventricular beta1 AR and beta2 AR mRNA levels in MI boundary region were measured.In comparison with control group,beta1 AR mRNA levels decreased gradually(P 0.05), whereas the change of beta2 AR had no statistical significance. The ratio between beta2 AR and beta AR increased from 17%to 38%(P 0.01). ICI 118 551 had the effects of increasing VFT in the 4 and 8 weeks groups after MI(P 0.05),and the effects had a strong positive correlation with the ratio between beta2 AR and beta AR mRNA levels(r=0.99,P 0.05).[Conclusion]The ratio between beta2 AR and beta AR increased gradually,and the increasing effect of beta2 adrenergic blocker on ventricular fibrillation threshold is also crescent.The ratio had a positive correlation with the effect." @default.
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- W2349569892 date "2004-01-01" @default.
- W2349569892 modified "2023-09-23" @default.
- W2349569892 title "Change of β_2 Adrenergic Receptor and Effects of Its Blocker on Ventricular Fibrillation Threshold After Myocardial Infarction" @default.
- W2349569892 hasPublicationYear "2004" @default.
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