Matches in SemOpenAlex for { <https://semopenalex.org/work/W2349606987> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2349606987 abstract "Objective To investigate the sensitivity of ADx-ARMS method for the detection of EGFR gene mutations in small biopsy samples of non-small cell lung cancer(NSCLC) compared with PCR-Sanger sequencing,and evaluate the clinical value of small biopsy samples for the detection of EGFR gene mutations. Methods A total of 98 specimens were obtained from 95 patients of Peking University People's Hospital during 2012 to 2013. The mutations in exons 18,19,20 and 21 of EGFR were detected by both PCR-Sanger sequencing and ADx-ARMS. The correlations between EGFR mutations and clinico-pathological parameters were analyzed. Results Of98 tumor samples,the detectable rate of EGFR mutation by ADx-ARMS was 51. 0%(50 samples),and that of PCR-Sanger sequencing was 25. 3%(24 samples). EGFR mutations were more frequently observed in females(65. 1%),non-smokers(64. 0%) and the patients with adenocarcinoma(51. 9%). Among the patients receiving tyrosine kinase inhibitor(TKI) therapy,the patients without EGFR mutation had shorter progression free survival(PFS)(2. 0 months) than those with EGFR mutation defined by either both ADx-ARMS and PCR-Sanger sequencing(9. 1 months) or ADx-ARMS only(10. 0 months,P 0. 01). Conclusion Small biopsy samples may be used for detection of EGFR mutation in the cases of unachievable surgical specimens. Compared with PCR-Sanger sequencing,ADx-ARMS method showed higher sensitivity,so it should be more suitable for detection of gene mutation in small biopsy samples." @default.
- W2349606987 created "2016-06-24" @default.
- W2349606987 creator A5065019633 @default.
- W2349606987 date "2014-01-01" @default.
- W2349606987 modified "2023-09-23" @default.
- W2349606987 title "Comparison between ADx-ARMS and PCR-Sanger sequencing for EGFR mutation detection in small biopsy samples of nonsmall cell lung cancer" @default.
- W2349606987 hasPublicationYear "2014" @default.
- W2349606987 type Work @default.
- W2349606987 sameAs 2349606987 @default.
- W2349606987 citedByCount "0" @default.
- W2349606987 crossrefType "journal-article" @default.
- W2349606987 hasAuthorship W2349606987A5065019633 @default.
- W2349606987 hasConcept C104317684 @default.
- W2349606987 hasConcept C121608353 @default.
- W2349606987 hasConcept C126322002 @default.
- W2349606987 hasConcept C142724271 @default.
- W2349606987 hasConcept C143998085 @default.
- W2349606987 hasConcept C153911025 @default.
- W2349606987 hasConcept C176944494 @default.
- W2349606987 hasConcept C2775934546 @default.
- W2349606987 hasConcept C2776256026 @default.
- W2349606987 hasConcept C2781182431 @default.
- W2349606987 hasConcept C2994225774 @default.
- W2349606987 hasConcept C501734568 @default.
- W2349606987 hasConcept C502942594 @default.
- W2349606987 hasConcept C50524450 @default.
- W2349606987 hasConcept C54355233 @default.
- W2349606987 hasConcept C71924100 @default.
- W2349606987 hasConcept C76818968 @default.
- W2349606987 hasConcept C86803240 @default.
- W2349606987 hasConceptScore W2349606987C104317684 @default.
- W2349606987 hasConceptScore W2349606987C121608353 @default.
- W2349606987 hasConceptScore W2349606987C126322002 @default.
- W2349606987 hasConceptScore W2349606987C142724271 @default.
- W2349606987 hasConceptScore W2349606987C143998085 @default.
- W2349606987 hasConceptScore W2349606987C153911025 @default.
- W2349606987 hasConceptScore W2349606987C176944494 @default.
- W2349606987 hasConceptScore W2349606987C2775934546 @default.
- W2349606987 hasConceptScore W2349606987C2776256026 @default.
- W2349606987 hasConceptScore W2349606987C2781182431 @default.
- W2349606987 hasConceptScore W2349606987C2994225774 @default.
- W2349606987 hasConceptScore W2349606987C501734568 @default.
- W2349606987 hasConceptScore W2349606987C502942594 @default.
- W2349606987 hasConceptScore W2349606987C50524450 @default.
- W2349606987 hasConceptScore W2349606987C54355233 @default.
- W2349606987 hasConceptScore W2349606987C71924100 @default.
- W2349606987 hasConceptScore W2349606987C76818968 @default.
- W2349606987 hasConceptScore W2349606987C86803240 @default.
- W2349606987 hasLocation W23496069871 @default.
- W2349606987 hasOpenAccess W2349606987 @default.
- W2349606987 hasPrimaryLocation W23496069871 @default.
- W2349606987 hasRelatedWork W1495275986 @default.
- W2349606987 hasRelatedWork W1506660188 @default.
- W2349606987 hasRelatedWork W1537739712 @default.
- W2349606987 hasRelatedWork W1830645850 @default.
- W2349606987 hasRelatedWork W2008550599 @default.
- W2349606987 hasRelatedWork W2079294958 @default.
- W2349606987 hasRelatedWork W2087058708 @default.
- W2349606987 hasRelatedWork W2150592804 @default.
- W2349606987 hasRelatedWork W2280747130 @default.
- W2349606987 hasRelatedWork W2355502275 @default.
- W2349606987 hasRelatedWork W2359947202 @default.
- W2349606987 hasRelatedWork W2366293227 @default.
- W2349606987 hasRelatedWork W2375639261 @default.
- W2349606987 hasRelatedWork W2773147801 @default.
- W2349606987 hasRelatedWork W2778664382 @default.
- W2349606987 hasRelatedWork W2995238620 @default.
- W2349606987 hasRelatedWork W3004856657 @default.
- W2349606987 hasRelatedWork W3008777973 @default.
- W2349606987 hasRelatedWork W3012494732 @default.
- W2349606987 hasRelatedWork W3024777808 @default.
- W2349606987 isParatext "false" @default.
- W2349606987 isRetracted "false" @default.
- W2349606987 magId "2349606987" @default.
- W2349606987 workType "article" @default.