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- W2349623831 abstract "Objective: To learn about the apoptosis role of HL-60 cells induced by DNR in vitro and the expression change of some protein. Methods: This study observed the apoptosis of HL-60 by optic microscope ,flow cytometry (FCM) and DNA electrophoresis and detected changes of various apoptosis-associated proteins expression with immunocytochemistry (IC) and FCM assays. Results: When treated with 0.2μM～2μM DNR , the percentage of apoptotic HL-60 cells increased with the increase of dose and the extension of time, and there showed the typical apoptotic cells and the appearance of apoptotic DNA ladder . It was shown that after HL-60 cells were treated with 1uM DNR for 2h, the fluorescence intensity index(FI) of both bcl-2 and c-myc decreased ,bax and caspase-3 increased; at 5h, the FI of bax and caspase-3 decreased on the contrary. Conclusion: It is suggested from the results that at the certain concentration, DNR can induce the apoptosis of HL-60 in vitro , and it can suppress the expression of bcl-2,c-myc and activate bax and caspase-3." @default.
- W2349623831 created "2016-06-24" @default.
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- W2349623831 date "2002-01-01" @default.
- W2349623831 modified "2023-09-23" @default.
- W2349623831 title "The apoptosis effect of daunorubicin on HL-60 cells in vitro" @default.
- W2349623831 hasPublicationYear "2002" @default.
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