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- W2349647686 abstract "Objective:To evaluate the impact factors of fecal short chain fatty acids(SCFA)and the effects of SCFA on apoptosis in colorectal carcinoma(CRC)patients.Methods:Patients who were initially diagnosed with colorectal carcinoma and able to tolerate radical operation were enrolled in our study.Descriptive data(age,gender,family history of cancer,alcohol consumption and cigarette),tumor data(size,location,clinical stage,migration),nutritional data(height,body weight,hemoglobin,serum albumin)were obtained at admission.Dietary intake was based on food frequency table which was completed by nutritionist at the same time.Apoptosis of tumor cells was evaluated by tunnel method and fecal concentration of SCFA was measured by ion-exclusion chromatography.Results:35 CRC patients were enrolled in our study.Among them,six were left hemicolon carcinoma,12 were right hemicolon carcinoma,and 17 were rectal carcinoma.Frequency of vegetable was in normal range in most of CRC patients while coarse grains,milk,yogurt and fruit intake were obviously lower than recommendation.Age,gender,location of tumor,clinical stage,frequency of vegetable,fruit and coarse grains,alcohol consumption,and family history of CRC showed no obviously effects on the concentration of fecal SCFA.However,no cigarettesmoking decreased and more yogurt intakes increased fecal concentration of SCFA in these CRC patients.Conclusion:Cigarette smoking and less yogurt intake may decrease fecal concentration of butyrate.Apoptosis in CRC tends to vary according to fecal butyrate concentration." @default.
- W2349647686 created "2016-06-24" @default.
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- W2349647686 date "2013-01-01" @default.
- W2349647686 modified "2023-09-25" @default.
- W2349647686 title "The impact factors of fecal short chain fatty acids and its effects on apoptosis in colorectal carcinoma patients" @default.
- W2349647686 hasPublicationYear "2013" @default.
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