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- W2349649694 abstract "Objective To analyze the relationship between these auto-antibodies(anti-nucleosome,AnuA;anti-C1q;anti-dsDNA anti-bodies)with theactivity of systemic lupus erythematosus Methods Examine anti-nucleosome antibodies,anti-C1q antibodies and anti-dsDNA antibodies in the sera of 33 patients with LN and 43 patients of systemic lupus erythematosus without renal damage.Then apart all samples to two groups by SLEDAI to analyze the correlate between the concentration and disease activity.Results Anti-nucleosome antibodies,anti-C1q antibodies and anti-dsDNA antibodies were significantly higher in LN than in control(P0.01).and also higher than the normal group.The same phenomena exist the SLEDAI(systemic lupus erythematosus disease activity index,SLEDAI)≥10 group.The three auto-antibodies have high sensitivity and specificity,the sensitivity and specificity of three auto-antilbodies combined determination is 66.7%,85.7%.These autoantibodies level was positively correlated with the score of SLEDAI.In multivariate analysis the factors associate with LN and SLEDAI were anti-nrcleosome antibodies,anti-C1q antibodies,anti-ds DNA antibodies.Conclusion in patients with LN or SLEDAI≥10 anti-nucleosome antibodies.ante-C1q antibodies and and anti-ds DNA antibodies are significantly higher than control groups.These antibodies are suggested to be diagnositc tools to reflect the activity systemic lupus erythematosus." @default.
- W2349649694 created "2016-06-24" @default.
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- W2349649694 date "2007-01-01" @default.
- W2349649694 modified "2023-09-22" @default.
- W2349649694 title "Evaluation the significance of serum anti-nucleosome Ab,anti-C1q Ab and anti-dsDNA Ab in the activity of systemic lupus erythematosus" @default.
- W2349649694 hasPublicationYear "2007" @default.
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