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- W2349654490 abstract "Objective To investigate the mechanism of desensitization of β 1-adrenoceptor(β 1-AR) during myocardial ischemia. Methods Myocardial ischemia models of rats were induced by given a booster doses of pituitrin. The density of β 1-AR on cardiac membranes was detected by radioligand binding assay. The cAMP levels of plasma and myocardium were detected by radioimmunoassay. The mRNA expression of β-AR and β-adrenoceptor kinase (β-ARK) were detected by RT-PCR assay. Results In cardiac membranes of ischemic myocardium the density of β-AR were increased but the affinity were decreased. The cAMP levels in plasma and myocardium of myocardial ischemia group were lower than control group(P0 01 or P0 05). The mRNA expression of β ARK-1 were significantly increased in the ischemic group. Conclusion There is a division tendency between the amount and function of β 1-AR during myocardial ischemia. It is caused by the desensitization of β 1-AR. The mechanism of desensitization is due to the increasing of mRNA expression of β ARK-1." @default.
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- W2349654490 modified "2023-09-25" @default.
- W2349654490 title "Desensitization of β-adrenoceptor During Myocardial Ischemia and Mechanism Investigation" @default.
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