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- W2349655833 abstract "Objective To study the combined effects of lead and cadmium on reproductive system of male mice.Methods Forty healthy adult Kunming male mice of clean grade were randomly divided into four groups,10 in each,control group(distilled water),lead group(800 mg/L),cadmium group(100 mg/L) and lead(800 mg/L) plus cadmium(100 mg/L) group.The animals were treated with the toxicants through drinking water,for 28 consecutive days.When the administration finished,the mice were weighed,and the testis and epididymis were separated rapidly.The organ coefficients of testis were calculated,the concentration of malondialdehyde and the activity of superoxide dismutase in the testis were determined,and teratosperms were examined under microscope.Results The weight of experimental groups was lower at the 21st day(P0.05),the organ coefficients of testis of experimental group were significantly higher compared with the control(P0.05).The concentration of MDA and rate of teratosperms in experimental groups increased significantly compared with the control,however the activity of SOD decreased significantly(P0.05).In addition,the concentration of MDA and rate of teratosperms in lead or cadmium group were lower than those in the lead plus cadmium group,and the activity of SOD were higher(P0.05).Conclusion The simultaneous exposure to lead and cadmium can cause oxidative stress-induced damage in reproductive system of male mice and result in teratosperm,and synergistic effect may be concerned." @default.
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- W2349655833 date "2011-01-01" @default.
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- W2349655833 title "Oxidative Damage Effect of Lead and Cadmium in Combination in Reproductive System of Male Mice" @default.
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