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- W2349656224 abstract "Objective To investigate the clinicopathological features of angniomylipoma ( AML) and epithelioid angniomylipoma (EAML),and their diagnosis and differential diagnosis. Methods Ten cases of AML and its subtypes EAML were studied with light microscopy and immunohistochemical staining,following-up and review of the literature. Results There were 4 cases of classical type,1 leiomyomatous type (fusiform and epitheloid cells),and 5 epitheloid type. There were 4 tumors arising from the kidney,liver and uterine. The tumor cells showed epitheloid,loosely arranged,irregular nodules or a sheet pattern,and surrounded the vessels,and the tumor cells had round nuclei,mild atypia and rare mitosis (1 /50 HPF); 1 case was arised from broad ligament,in which the tumor cells appeared epithelioid,large nuclei,atypia,intranuclear inclusion,and more mitotic figures (1 /10 HPF),and the plasma was acidophilia,with necrosis. The tumor invaded ovaries and cavitas pelvis of the same side. After followed up for 5 years,this case was suspicious recurrence with liver metastasis. But there was no recurrence and metastasis in other cases. Immunohistochemical staining showed the tumor cells were positive for HMB-45,Melan-A and SMA,partially for desmin,but negative for S-100 protain,CD34,CK,EMA,and CgA. Conclusions AML usually is a benign tumor,but malignant transformation should be considered if appearence of necrosis,increased nuclear activity and atypia and spread out of the kidney. Any EAML case should be followed intimately up even if it seems benign morphologically,and it is also differentially diagnosed with tumors with similar morphology." @default.
- W2349656224 created "2016-06-24" @default.
- W2349656224 creator A5087923013 @default.
- W2349656224 date "2010-01-01" @default.
- W2349656224 modified "2023-09-25" @default.
- W2349656224 title "Angiomyolipoma:a clinicopathologic analysis of 10 cases" @default.
- W2349656224 hasPublicationYear "2010" @default.
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