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- W2349659648 abstract "Objective To investigate the expression of MMP 9 and VEGF genes in primary hepatocellular carcinoma (HCC) and explore its relation to invasion and metastasis of the tumor. Methods RT PCR was used to detect MMP 9 and VEGF mRNA in surgically extracted specimens from 41 patients with HCC. Results The rate of positive expression of MMP 9 was 70 7%, 48 9% and 41 5% while that of VEGF was 75 6%, 53 7% and 46 3% in tumor tissue, 1 cm adjacent tissue and 5 cm adjacent tissue, respectively. The expression of MMP 9 and VEGF was significantly higher in tumor tissue than in 5 cm adjacent tissue (P0 01). Meanwhile, the expression of MMP 9 and VEGF was significantly higher in tumors with pv emboli or poor encapsulated tumors than in those without pv emboli or well encapsulated tumors (P0 05). The expression of MMP 9 was markedly related to HCC recurrence and AFP positivity. Conclusions The expression of MMP 9 and VEGF is closely correlated to recurrence or metastasis of HCC. MMP 9 expression level can be used as a predictor for prognosis of HCC." @default.
- W2349659648 created "2016-06-24" @default.
- W2349659648 creator A5029818365 @default.
- W2349659648 date "2003-01-01" @default.
- W2349659648 modified "2023-09-23" @default.
- W2349659648 title "Significance of MMP and VEGF mRNA expression in invasion and metastasis of hepatocellular carcinoma" @default.
- W2349659648 hasPublicationYear "2003" @default.
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